Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors

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5a-reductase inhibitors and prostate cancer Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with shorter time to diagnosis and worse mortality in prostate cancer, according to findings from veterans affairs electronic health records.

Benign prostatic hyperplasia (BPH), also known as benign prostatic hypertrophy, is a histologic diagnosis characterized by proliferation of the cellular elements of the prostate. Cellular accumulation and gland enlargement may result from epithelial and stromal proliferation, impaired preprogrammed cell death (apoptosis), or both.

Men receiving a 5-alpha reductase inhibitor (5-ARI) for treatment of benign prostatic hypertrophy who developed prostate cancer were more likely to have a delay in diagnosis as well as worse.

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In men with prostate cancer, delayed diagnosis and worse cancer-specific outcomes are linked to prediagnostic use of 5-ARIs. These data highlight an ongoing need to raise awareness of 5-ARI-induced suppression of PSA, set clear guidelines for early detection of prostate cancer, and motivate system-based practices to facilitate optimal care for.

 · Two years ago he was started on a 5-alpha reductase inhibitor and an alpha-blocker for worsening BPH symptoms. His BPH symptoms are currently under control, with an American Urological Association (AUA) symptom index score of 7 of a possible 35 (higher scores being worse).

Worse Prostate Cancer Outcomes With 5-Alpha-Reductase Inhibitors. _____ Treatment with 5-alpha-reductase inhibitors (5-ARIs) is associated with shorter time to diagnosis and worse mortality in prostate cancer, according to findings from Veterans Affairs electronic health records.

96. Background: To investigate the impact of 5-alpha-reductase inhibitors (5-ARIs) usage on radiotherapy outcomes for localized prostate cancer.Methods: From our institutional database of over 2500 patients, we identified 203 patients on a 5-ARI. They were all treated with either external beam radiotherapy (EBRT) or brachytherapy for localized prostate cancer.

Comparison of Total Gland HIFU and Focal HIFU. Having total gland HIFU means that no area of the prostate is spared. It is appropriate when both sides of the prostate contain multiple or large areas of cancer cells. Below are some of the advantages of total gland HIFU: When there are many areas of the prostate that contain cancer,

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